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LOSARTAN + HYDROCHLOROTHIAZIDE
AnzaPlusTM
50mg/ 12.5mg Tablet
Anti-Hypertensive/Diuretic
FORMULATION:
Each film-coated tablet contains:
Losartan Potassium ………….............................. 50 mg
Hydrochlorothiazide ……………........................... 12.5 mg |
PHARMACOLOGY
Angiotensin converting enzyme is a non-specific enzyme and plays a crucial role in the conversion of
Angiotensin I to Angiotensin II. Angiotensin II (ANG II) is a potent vasoconstrictor and an important
component incriminated in the pathophysiology of hypertension. It elicits its actions through two known
membrane receptors, AT1 and AT2. The effects mediated through AT1 receptors include vasoconstriction,
aldosterone stimulation and salt and water retention. The role of AT2 receptors in cardiovascular
homeostasis is not yet established. Losartan potassium selectively antagonizes binding of ANG II to AT1
receptors. Consequently, further effects of ANG II are blocked. As a supporting role, Losartan potassium’s
carboxylic acid metabolite also selectively blocks AT1 receptors. One of the strategies in the management
of hypertension is to alter body sodium levels by restriction of salt in the diet. Pharmacologically also,
sodium levels can be altered with the help of diuretics. Hydrochlorothiazide affects electrolyte
reabsorption at the level of distal convulated tubule and increases the excretion of sodium and chloride in
approximately amounts by its inhibitory effects on Na Cl symport located in luminal membrane.
INDICATION :
Losartan + Hydrochlorothiazide is indicated for the treatment of hypertension.
DOSAGE AND ADMINISTRATION:
The usual dosage recommended is one tablet daily in the morning. The usual daily dosage recommended
for the treatment of hypertension is 25-100 mg and 25-50 mg for Losartan and Hydrochlorothiazide,
respectively. Use lower starting doses in patients having impaired renal or hepatic function. Adjust the
doses to a minimum effective strength in elderly patients on Hydrochlorothiazide. Losartan potassium can
be given with or without food.
Or as prescribed by the physician.
CONTRAINDICATION :
Losartan + Hydrochlorothiazide is contraindicated in patients who are sensitive to either drug & to other
sulfonamide derived drugs; anuria; pregnancy and breastfeeding mothers.
ADVERSE EFFECTS:
The adverse effects reported frequently include headache, dizziness, asthenia/fatigue. Other effects include
first dose hypotension, skin rah, oedema, transient elevation of liver enzymes, hyperkalemia and taste
disturbances. According to clinical trials, albeit cough has not been reported as a specific drug-related event
with Losartan potassium, the incidence of cough experienced is comparable to that of placebo. The adverse
effects frequently experienced with Hydrochlorothiazide include electrolyte imbalance, glycosuria,
hyperglycaemia, hyperuricemia and weakness. Other side effects include gastrointestinal disturbances,
headaches, dizziness, photosensitivity reactions, postural hypotension, paresthesia, impotence, xanthopsia,
hypersensitivity, cholestatic jaundice, pancreatitis and blood dyscrasias. Hypokalemia may be produced by
hydrochlorothiazide.
PRECAUTIONS:
In patients having intravascular volume depletion, either lower dose of Losartan potassium should be used,
or salt and volume deletion should be corrected prior to Losartan potassium therapy.
AVAILABILITY
Losartan + Hydrochlorothiazide 50mg/ 12.5mg Tablet in alu-alu foil pack of 3 x 10 tablets
CAUTION:
Foods, Drugs, Devices, and Cosmetics Act prohibits dispensing without prescription.
STORE AT TEMPERATURES NOT EXCEEDING 30° C.
AnzaPlus is a trademark of XENO Pharmaceuticals Phils. Inc.
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